Health-Related Quality of Life (QOL) in Metastatic Breast Cancer Patients Treated With Everolimus and Exemestane Versus Exemestane Monotherapy
نویسندگان
چکیده
منابع مشابه
Efficacy of everolimus with exemestane versus exemestane alone in Asian patients with HER2-negative, hormone-receptor-positive breast cancer in BOLERO-2
BACKGROUND The addition of mTOR inhibitor everolimus (EVE) to exemestane (EXE) was evaluated in an international, phase 3 study (BOLERO-2) in patients with hormone-receptor-positive (HR(+)) breast cancer refractory to letrozole or anastrozole. The safety and efficacy of anticancer treatments may be influenced by ethnicity (Sekine et al. in Br J Cancer 99:1757-62, 2008). Safety and efficacy resu...
متن کاملEfficacy of Exemestane in Korean Patients with Metastatic Breast Cancer after Failure of Nonsteroidal Aromatase Inhibitors
PURPOSE Exemestane has shown good efficacy and tolerability in postmenopausal women with hormone receptor-positive metastatic breast cancer. However, clinical outcomes in Korean patients have not yet been reported. METHODS Data on 112 postmenopausal women with metastatic breast cancer were obtained retrospectively. Clinicopathological characteristics and treatment history were extracted from ...
متن کاملAnastrozole Versus Exemestane in Patients with Postmenopausal Breast Cancer and Visceral Metastases
Background: For patients with hormone receptor positive metastatic breast cancer (MBC), both steroidal and non-steroidal aromatase inhibitors (AIs) have demonstrated efficacy as initial and subsequent lines of treatment in trials comparing them with other hormonal agents like tamoxifen and megestrol acetate. Patients with MBC and predominant visceral involvement have a shortened survival compar...
متن کاملAbiraterone acetate, exemestane or the combination in postmenopausal patients with estrogen receptor-positive metastatic breast cancer†
BACKGROUND Androgen receptor (AR) signaling and incomplete inhibition of estrogen signaling may contribute to metastatic breast cancer (MBC) resistance to a nonsteroidal aromatase inhibitor (NSAI; letrozole or anastrozole). We assessed whether combined inhibition of androgen biosynthesis with abiraterone acetate plus prednisone and estradiol synthesis with exemestane (E) may be of clinical bene...
متن کاملHealth-Related Quality of Life and its related factors among women with breast cancer
Introduction: Breast cancer is an important issue in chronic disease studies. Breast cancer is the most common cancer among women.Life expectancy is long in patients with breast cancer and in result they suffer longer from cancer and its complications.Therefore it seems necessary to determine QOL and its related-factors in these patients. Objective: The purpose of the study isto determine Quali...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2012
ISSN: 0923-7534
DOI: 10.1016/s0923-7534(20)32894-5